{"id":1623,"date":"2026-03-17T13:32:26","date_gmt":"2026-03-17T13:32:26","guid":{"rendered":"https:\/\/r8993.hemsida.eu\/swedness\/?post_type=project&#038;p=1623"},"modified":"2026-03-18T12:55:26","modified_gmt":"2026-03-18T12:55:26","slug":"alpha-synuclein-amyloid-fibrils-and-interactions-with-lipid-membranes-2","status":"publish","type":"project","link":"https:\/\/r8993.hemsida.eu\/swedness\/projects\/alpha-synuclein-amyloid-fibrils-and-interactions-with-lipid-membranes-2\/","title":{"rendered":"Alpha-Synuclein: Amyloid Fibrils and Interactions with Lipid Membranes"},"content":{"rendered":"\n<p>This project examined the molecular mechanisms by which&nbsp;<strong>alpha-synuclein<\/strong>, a key protein implicated in&nbsp;<strong>Parkinson\u2019s disease<\/strong>, interacts with&nbsp;<strong>lipid membranes<\/strong>&nbsp;and forms&nbsp;<strong>amyloid fibrils<\/strong>, the main components of Lewy bodies found in affected neurons. Using&nbsp;<strong>small-angle neutron scattering (SANS)<\/strong>&nbsp;and&nbsp;<strong>small-angle X-ray scattering (SAXS)<\/strong>, the research characterized the structures of alpha-synuclein in both its&nbsp;<strong>monomeric and fibrillar states<\/strong>, as well as its interactions with different model lipid systems.<\/p>\n\n\n\n<p>The studies revealed that monomeric alpha-synuclein deforms lipid micelles, with partial recovery upon fibril formation, and that fibrillation can induce&nbsp;<strong>vesicle fusion<\/strong>&nbsp;without incorporating lipids into the fibril structure. Moreover,&nbsp;<strong>colloidally unstable fibrils<\/strong>&nbsp;were found to cluster independently of the surrounding lipid environment.<\/p>\n\n\n\n<p>By combining neutron and X-ray scattering, this work provided new structural insights into the&nbsp;<strong>protein\u2013membrane interactions<\/strong>&nbsp;underlying amyloid formation, contributing to a better understanding of&nbsp;<strong>the molecular processes involved in Parkinson\u2019s disease<\/strong>.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD: Marija Dubackic, Lund University (2021)<\/p>\n","protected":false},"featured_media":0,"template":"","project_category":[50],"research_theme":[42],"class_list":["post-1623","project","type-project","status-publish","hentry","project_category-former","research_theme-life-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project\/1623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":1,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project\/1623\/revisions"}],"predecessor-version":[{"id":1624,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project\/1623\/revisions\/1624"}],"wp:attachment":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/media?parent=1623"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project_category?post=1623"},{"taxonomy":"research_theme","embeddable":true,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/research_theme?post=1623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}