{"id":1629,"date":"2026-03-17T13:34:04","date_gmt":"2026-03-17T13:34:04","guid":{"rendered":"https:\/\/r8993.hemsida.eu\/swedness\/?post_type=project&#038;p=1629"},"modified":"2026-03-18T12:55:26","modified_gmt":"2026-03-18T12:55:26","slug":"small-angle-scattering-as-a-tool-to-study-protein-structure-and-interactions","status":"publish","type":"project","link":"https:\/\/r8993.hemsida.eu\/swedness\/projects\/small-angle-scattering-as-a-tool-to-study-protein-structure-and-interactions\/","title":{"rendered":"Small-Angle Scattering as a Tool to Study Protein Structure and Interactions"},"content":{"rendered":"\n<p>This project investigated how&nbsp;<strong>small-angle neutron and X-ray scattering (SANS\/SAXS)<\/strong>&nbsp;can be used to uncover the structural and functional mechanisms underlying essential biological processes in both bacteria and humans. By combining neutron scattering with molecular dynamics simulations and biophysical modelling, the research provided new understanding of&nbsp;<strong>protein\u2013DNA binding<\/strong><strong>,<\/strong><strong>&nbsp;<\/strong><strong>viral protein flexibility<\/strong>, and&nbsp;<strong>ubiquitin-mediated enzymatic processes<\/strong>.<\/p>\n\n\n\n<p>The studies demonstrated how scattering techniques made it possible to explore complex biomolecular systems directly in solution, revealing conformational dynamics critical for understanding&nbsp;<strong>antibiotic resistance regulation<\/strong><strong>,<\/strong><strong>&nbsp;<\/strong><strong>viral infection pathways<\/strong><strong>, <\/strong>and&nbsp;<strong>protein modification mechanisms<\/strong>. The work also introduced methodological developments for&nbsp;<strong>contrast-variation SANS<\/strong>&nbsp;experiments, expanding the use of neutron scattering in&nbsp;<strong>protein science and drug discovery<\/strong>&nbsp;within the life-science field.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD: Zuzanna Pietras, Link\u00f6ping University (2022)<\/p>\n","protected":false},"featured_media":0,"template":"","project_category":[50],"research_theme":[42],"class_list":["post-1629","project","type-project","status-publish","hentry","project_category-former","research_theme-life-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project\/1629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/types\/project"}],"version-history":[{"count":1,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project\/1629\/revisions"}],"predecessor-version":[{"id":1630,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project\/1629\/revisions\/1630"}],"wp:attachment":[{"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/media?parent=1629"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/project_category?post=1629"},{"taxonomy":"research_theme","embeddable":true,"href":"https:\/\/r8993.hemsida.eu\/swedness\/wp-json\/wp\/v2\/research_theme?post=1629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}